Natural Choices are indeed better.. especially when proven by science

Milk Calcium, Phosphorus and Vitamin D Tablets

“ 1/3 Women over 50 will experience osteoporotic fractures. As will 1/4 men.”

Worldwide, 1 in 3 women over age 50 will experience osteoporotic fractures, as will 1 in 5 men aged over 50

By 2050, the worldwide incidence of hip fracture in men is projected to increase by 310% and 240% in women, compared to rates in 1990.

Mortality rates post-hip fracture vary between 25-30% in western populations, they are 2-3 fold higher in populations from the Middle East and Africa region.

CALCIUM INTAKE FROM FOOD AND SUPPLEMENT

Although calcium intake is indeed a risk factor; Over the age of 50 in Women, majority of calcium intake is through supplementation.

BUT WHY IS OSTEOPOROSIS INCREASING IN THIS AGE GROUP?.

Is Supplements the right choice??

SUPPLEMENTS VSDietary Calcium

	Milk Calcium	Calcium supplement
Drug Interactions	The calcium is protected by the Casein phosphopeptides (CPP) and hence interactions are far fewer.	Calcium supplements can interact with several medications: the absorption of calcium from calcium carbonate is reduced by proton pump inhibitors, while calcium supplements may interact with antibiotics, thiazide diuretics, digoxin and phenytoin.
Absorption	Active and Passive transport. Casein phosphopeptides (CPP) bind calcium and therefore protect it against precipitation with anions such as phosphates in the small intestine. The net result is an increase of passive calcium absorption in the ileum	Transcellular pathway (active transport) account for majority of absorbtion.
Vitamin D deficiency	Can be also absorbed by the influence of lactose in the distal small intestine via the paracellular route. Thus milk can provide calcium with “ensured absorbability” which is generally insensitive to external factors.	Impacts calcium absorption.
Absorbtion inhibitors	No Effect of inhibitors, as calcium is protected in CPP.	Supplemental calcium absorbtion is inhibited by phytates, oxalates, uronic acids or polyphenols in diet.
Calcium utilization	The availability of calcium for bone mineralization appears to be greater for dairy foods and the effects are longer lasting.	Absorbtion of calcium is non inferior to dairy calcium but utilization in bone is less.
Phosphorous content	Increased inorganic phosphate intake leads to decreased urinary calcium and increased calcium retention. calcium and inorganic phosphate in a ratio close to that found in dairy products leads to positive effects on bone health.	Conventional supplements have no phosphorous.
PPI usage/ achlorhydria	Milk calcium is bound to peptides and proteins making it efficacious.	Impaired acid levels impact calcium absorbtion.
Meal Effect	Provide an almost complete diet whose consumption provides a “meal effect”. This fosters the absorption of calcium and provides a simultaneous intake of phosphorus that is essential for bone deposition.	Calcium supplements do not contain the additional nutrients—including protein, phosphorous and magnesium.

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Clinical advantages in pregnancy

In 111,184 pregnant women study, the consumption of higher amount of Milk & related products was associated with a reduced risk of small-for-gestational age(SGA) (OR = 0.69,95%CI: 0.56-84) and low birth weight infants (OR= 0.63, 95 % CI: 0.48% - 0.84 )

Milk reduces preterm birth

Calcium reduces the risk of preterm delivery in women with low calcium intakes by 24%. The mode of action of calcium is that it reduces parathyroid release and intercellular calcium so reduces smooth muscle contractility.

Supplimentation need in pregnancy

The skeleton of a new baby contains approximately 20-30 g of calcium. The increase in calcium absorption is directly related to maternal calcium intake . During pregnancy 57% is absorbed during the second trimester and 72% during third trimester.

Calcium maternal advantage

Daily supplementation of elemental calcium in pregnancy was associated with 66.7% risk reduction in developing preeclampsia. Low calcium intakes during pregnancy may stimulate PTH secretion, increasing intracellular calcium and smooth muscle contractibility and/or release renin from the kidney, leading to vasoconstriction and retention of sodium and fluid.

Calcium needs for the fetus

Fetal calcium levels suggest that ionized calcium is transferred from the mother to the fetus at a rate of 50mg/day at 20 weeks of gestation to a maximum of 330 mg/day at 35 weeks of gestation.

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Milk: Prevent tooth decay and help strengthen tooth enamel

When combined with calcium and prosperous, casein creates a protective protein film over the enamel surface of the tooth. This has the ability to reduce the risk of tooth decay and decrease enamel strength.

Milk: Prevent tooth loss

A 10-fold increase in diary calcium intake was significantly associated with a decreased risk of tooth loss (incidence-rate ratio 0.32, 95% confidence interval 0.15 - 0.68)

Milk: Helps in mineralization

Diary products are good source of calcium, the casein phosphopeptides enhance calcium absorption and mineral retention.

Milk: Periodontitis and periodontal attachment loss

Higher daily intakes of milk may be protective against periodontitis and was inversely associated with severity of periodontal attachment loss.

CHANGING MINDSET

Consensus statement from the Belgian Bone Club :

For the non-pharmacological management of osteoporosis, single-nutrient supplements will frequently be inadequate and preference should go to the use of complete supplements or complete foods such as dairy products.

European guidance for the diagnosis and management of osteoporosis in postmenopausal women:

Calcium supplementation should only be targeted to those who do not get sufficient calcium from their diet and who are at high risk for osteoporosis and/or fracture.

TRIALS

Dairy calcium is non-inferior to calcium from mineral salts, the availability for bone mineralisation appears to be greater for dairy foods and the effects are longer lasting.

Postmenopausal women, those randomised to dairy calcium had greater improvements in arm, pelvis, total spine and total-body bone mineral density (BMD) than those receiving calcium supplements in one trial.

Greater increases in insulin-like growth factor-I (IGF-I), which favours bone formation, have also been reported for dairy compared with calcium supplements.

Each chewable tablet contains

Milk Calcium (Casein phosphopeptide complex) ............. 1200 mg
equivalent to bio optimized Calcium ......... 300 mg
Elemental Phosphorous .......................... 150 mg
Cholecalciferol (Vitamin D3) BP .................. 400 IU

Dosage: 1-2 tablets daily as recommended by your doctor